silagra incepta pharmaceutical

Posted on 24 Ноя 201712

Silagra - Incepta Pharmaceuticals | Product details

Silagra - Incepta Pharmaceuticals | Product details
One of the leading and fastest growing pharmaceuticals companies in Bangladesh. ... Silagra 50 tablet: Each tablet contains Sildenafil Citrate INN 70.24 mg ...

Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by Tadalafil has no effect in the absence of sexual stimulation. Patients on multiple antihypertensive medications were included in the pivotal clinical trials for Sildenafil. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. Agents for the treatment of erectile dysfunction, including Tadalafil, should not be used in men with cardiac disease for whom sexual activity is inadvisable. Single doses of up to 500 mg have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients.

The safety of Sildenafil is unknown in patients with bleeding disorders and patients with active peptic ulceration. No changes in Tadalafil concentrations were seen 3 hours after co-administration with alcohol. Treatment of erectile dysfunction, benign prostatic hyperplasia and erectile dysfunction with benign prostatic hyperplasia. In some patients, concomitant use of these two drug classes can lower blood pressure significantly leading to symptomatic hypotension (e. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum.

In a separate drug interaction study, when amlodipine, 5 mg or 10 mg, and Sildenafil, 100 mg were orally administered concomitantly to hypertensive patients mean additional blood pressure reduction of 8 mmHg systolic and 7 mmHg diastolic were noted. Cardiovascular and cerebrovascular: Serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages, and pulmonary hemorrhage have been reported post-marketing in temporal association with the use of Sildenafil. There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease. This is consistent with ritonavir\\\'s marked effects on a broad range of P450 substrates. Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of Sildenafil. Silagra 100 Tablet: Each box contains 1 blister strip of 4 film-coated tablets. Specific interaction studies with antidiabetic agents were not conducted. The adverse events reported with Tadalafil were transient, and generally mild or moderate. Others were reported to have occurred hours to days after the use of Sildenafil and sexual activity. Silagra 100 tablet: Each tablet contains Sildenafil Citrate INN 140.

Silagra 100 | mph Bangladesh
You are here: Home; Silagra 100 ... Silagra 100 · Incepta Pharmaceuticals Limited, Sildenafil Citrate INN 140.48 mg equivalent to Sildenafil 100 mg, Capsule ...

Manufacturer: Incepta Pharmaceuticals LimitedSilagra 50 tablet: Each tablet contains Sildenafil Citrate INN 70.24 mg equivalent to Sildenafil 50 mg.

Patients with cardiac failure or coronary artery disease causing unstable angina; • Patients with retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases); Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Sildenafil. Efficacy of Tadalafil may persist up to 24 hours post-dose. Metabolic and Nutritional: thirst, edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia. At 24 hours the plasma levels of Sildenafil were still approximately 200 ng/mL, compared to approximately 5 ng/mL when Sildenafil was dosed alone. It is not possible to determine whether these events are related directly to Sildenafil, to sexual activity, to the patient\\\'s underlying 23 cardiovascular disease, to a combination of these factors, or to other factors.

Sildenafil is indicated for the treatment of erectile dysfunction and pulmonary arterial hypertension. Although specific interactions have not been studied, some protease inhibitors, such as ritonavir and saquinavir, and other CYP3A4 inhibitors, such as erythromycin, clarithromycin, itraconazole and grapefruit juice, should be co-administered with caution as they would be expected to increase plasma concentrations of Tadalafil. PDE5 inhibitor, alpha-blocker therapy should be initiated at the lowest dose. To decrease the chance of adverse events in patients taking ritonavir, a decrease in Sildenafil dosage is recommended. Sildenafil is contraindicated in patients with a known hypersensitivity to any component of the tablet.

In some patients, concomitant use of these two drug classes can lower blood pressure significantly leading to symptomatic hypotension (e. The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of Sildenafil. Decreased blood pressure, syncope, and prolonged erection were reported in some healthy volunteers exposed to high doses of Sildenafil (200-800 mg). Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure when taking a PDE5 inhibitor. Geriatrics: Healthy elderly volunteers (65 years or over) had a reduced clearance of Sildenafil, resulting in approximately 84% and 107% higher plasma AUC values of Sildenafil compared to those seen in healthy younger volunteers. If Sildenafil is prescribed to patients taking ritonavir, caution should be used. When Sildenafil is taken with a high fat meal, the rate of absorption is reduced. Sildenafil was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors or nitrates in any form is therefore contraindicated. Although the interaction between other protease inhibitors and Sildenafil has not been studied, their concomitant use is expected to increase Sildenafil levels.

Silagra 100mg 4 Tablets/Pack (Sildenafil 100mg)

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